The pattern of inheritance in Danon Disease is called 'X-Linked
Dominant' inheritance. X-Linked inheritance is also referred to as 'Sex-Linked' inheritance.
In this type of inheritance
Danon Disease can be passed on from a parent to a child.
Typically, MOTHERS with Danon Disease will pass on the risk
of disease to approximately half of their sons AND daughters.
FATHERS with Danon Disease, however, will pass on the
risk of disease to ALL of their daughters but NONE of their sons.
X-Linked inheritance is explained
by the sex-chromosomes.
All of us carry the genetic material (called 'DNA') we inherited from our parents inside our
cells. The DNA is contained in structures called chromosomes. There are two sex chromosomes called 'X' and 'Y' and each of
us has two sex chromosomes in each of our cells.
Males have both an 'X' and a 'Y' sex chromosome.
Females have two
'X' chromosomes and no 'Y' chromosome.
The genetic problem ('mutation') in Danon Disease occurs on the 'X' chromosome.